Molecular NeuroBiology lab @ KBRI

Dissecting Learning and Memory!


"Something neat found in vitro is bound to be used somewhere in vivo"





2015 ~ current

  • Jhang J, Lee H, Kang MS, Park H, Han J-H, Anterior cingulate cortex and its input to the basolateral amygdala control innate fear response. Nature Communications. 2018, 9:2744. (co-corresponding author)

  • Park H, Cortical axonal secretion of BDNF in the striatum is disrupted in the mutant-huntingtin knock-in mouse model of Huntington's disease. Experimental Neurobiology. 2018, 27(3): 217-225.




Before 2015
  • Park H, Han KS, Seo J, Lee J, Dravid SM, Woo J, Chun H, Cho S, Bae JY, An H, Koh W, Yoon BE, Berlinguer-Palmini R, Mannaioni G, Traynelis SF, Bae YC, Choi SY, Lee CJ, Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Molecular Brain. 2015, Feb 3; 8(1):7.

  • Park H, Popescu A, Poo MM, Essential role of presynaptic NMDA receptors in activity-dependent BDNF secretion and corticostriatal LTP, Neuron. 2014 Dec 3; 84:1009-22.

  • Vazin T, Ball KA, Lu H, Park H, Ataeijannati Y, Head-Gordon T, Poo MM, Schaffer DV, Efficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: A model system to study neurotoxicity in Alzheimer's disease. Neurobiology of Disease. 2014 Feb 18; 62: 62-72

  • Park H, Han KS, Oh SJ, Jo S, Woo J, Yoon BE, Lee CJ, High glutamate permeability and distal localization of Best1 channel in CA1 hippocampal astrocyte. Molecular Brain. 2013 Dec 9;6(1):54.

  • Lu H, Park H, Poo MM, Spike Timing-dependent BDNF Secretion and Synaptic Plasticity. Philosophical Transactions B. 2013, Dec 2; 369(1633): 20130132

  • Han KS, Woo J, Park H, Yoon BJ, Choi S, Lee CJ, Channel-mediated astrocytic glutamate release via Bestrophin-1 targets synaptic NMDARs. Molecular Brain. 2013 Jan 16; 6: 4.

  • Park H, Poo MM. Neurotrophin regulation of neural circuit development and function. Nature Reviews Neuroscience. 2013 Jan;14(1): 7-23

  • Oh SJ, Han KS, Park H, Woo D, Kim HY, Traynelis SF, Lee CJ. Protease Activated Receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis. Molecular Brain. 2012 Oct 12;5(1):38

  • Lee S, Yoon BE, Berglund K, Oh SJ, Park H, Shin HS, Augustine GJ, Lee CJ. Channel-mediated tonic GABA release from glia. Science. 2010 Nov 5; 330(6005): 790-6.

  • Jang DJ, Park SW, Lee JA, Lee C, Chae YS, Park H, Kim MJ, Choi SL, Lee N, Kim H, Kaang BK. N termini of apPDE4 isoforms are responsible for targeting the isoforms to different cellular membranes. Learning and Memory. 2010 Sep 2; 17(9): 469-79. 

  • Park H, Oh SJ, Han KS, Woo DH, Park H, Mannaioni G, Traynelis SF, Lee CJ. Bestrophin-1 encodes for the Ca2+-activated anion channel in hippocampal astrocytes. Journal of Neuroscience.  2009 Oct 14; 29(41): 13063-73. 

  • Lee YS, Choi SL, Lee SH, Kim H, Park H, Lee N, Lee SH, Chae YS, Jang DJ, Kandel ER, Kaang BK. Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning-related heterosynaptic facilitation in Aplysia. Proc. Natl. Acad. Sci. USA. 2009 Aug 25; 106(34): 14634-9.

  • Park H, Pack C, Kinjo M, Kaang BK. In vivo quantitative analysis of PKA subunit interaction and cAMP measurement using dual color Fluorescence Cross Correlation Spectroscopy. Molecules and Cells. 2008 July 31; 26(1): 87-92. 

  • Kim BW, Choi M, Kim YS, Park H, Lee HR, Yun CO, Kim EJ, Choi JS, Kim S, Rhim H, Kaang BK, Son H. Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin. Cellular Signaling. 2008 Apr; 20(4): 714-25. 

  • Lee SH, Lim CS, Park H, Lee JA, Han JH, Kim H, Cheang YH, Lee SH, Lee YS, Ko HG, Jang DH, Kim HK, Miniaci MC, Bartsch D, Kim E, Bailey CH, Kandel ER, Kaang BK. Nuclear Translocation of apCAM-Associated Protein Activates Transcription for Long-Term Facilitation in Aplysia. Cell. 2007 May 18; 129(4): 801-12. (co-first author)

  • Yim SJ, Lee YS, Lee JA, Chang DJ, Han JH, Kim H, Park H, Jun H, Kim VN, Kaang BK. Regulation of ApC/EBP mRNA by the Aplysia AU-rich element-binding protein, ApELAV, and its effects on 5-hydroxytryptamine-induced long-term facilitation. Journal of Neurochemistry 2006 Jul;98 (2): 420-9.

  • Park H, Lee JA, Lee C, Kim MJ, Chang DJ, Kim H, Lee SH, Lee YS, Kaang BK. An Aplysia type 4 phosphodiesterase homolog localizes at the presynaptic terminals of Aplysia neuron and regulates synaptic facilitation. Journal of Neuroscience. 2005 Sep 28; 25(39): 9037-45.

  • Jang DH, Han JH, Lee SH, Lee YS, Park H, Lee SH, Kim H, Kaang BK. Cofilin expression induces cofilin-actin rod formation and disrupts synaptic structure and function in Aplysia synapses. Proc. Natl. Acad. Sci. USA. 2005 Nov 1; 102(44): 16072-7.