Molecular NeuroBiology lab @ KBRI

Dissecting Learning and Memory!

Research interests

Our research interests covers from molecular mechanisms for regulating synaptic plasticity regulating learning and memory to developing new tools for studying complex neural circuits.

Another "star" player in the field: astrocyte

model1


Proper regulation of neural circuit formation/elimination & plasticity is essential for normal cognitive functions including learning and memory. We are focusing on the role of glia cells, astrocytes, in regulating "neural synapses" in functional and structural levels. In addition, we are also interested in identifying novel molecular factors mediating neuron-glia interaction, which is involved in long-term synaptic plasticity and learning & memory processes.

Finding differences

model2
Based on basic findings about molecular mechanisms regulating normal cognitive functions, we aim to explore key mechanisms related with neurodegenerative diseases. By identifying certain mechanisms altered in the diseased circuits when compared to neuro-glia interactions in the normal neural circuits, our study will provide basic ideas for better diagnosing tools or treatments.

Exploring working mechanisms for working memory

PPC-PFC
Sustained neural activity in the cortex is thought to be the cellular mechanism of working-/short-term memory, but underlying mechanisms is still unclear. By focusing on the PPC-PFC circuit and utilizing several innovative molecular / viral vector tools, imaging, and slice physiology techniques, we would like to identify behaviorally-relevant PPC-PFC synapses and study their role in decision making behaviors.

You can see more if you have a tool.



tag system
Despite many available tools labeling specific types of cells and circuits for identifying behaviorally-relevant neural connectivity, neurobiologists are still eager to develop fine molecular tools for simultaneous labeling and manipulation of multiple cells/circuits, because multiple cells/circuits are concurrently involved in the simple brain function. By developing new viral vectors for selectively manipulating multiple gene expression in vivo, we aim to provide efficient genetic tools ideal for studying complex neural circuits regulating learning and memory.